![]() Metandienone has no progestogenic activity. The co-administration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like tamoxifen can reduce or prevent such estrogenic side effects. As such, it can cause side effects such as gynecomastia and fluid retention. While the rate of aromatization is reduced relative to that for testosterone or methyltestosterone, the estrogen produced is metabolism-resistant and hence metandienone retains moderate estrogenic activity. Metandienone is a substrate for aromatase and can be metabolized into the estrogen methylestradiol (17α-methylestradiol). As such, it is only really commonly used in men. Nonetheless, while the ratio of anabolic to androgenic activity of metandienone is improved relative to that of testosterone, the drug does still possess moderate androgenic activity and is capable of producing severe virilization in women and children. As such, 5α-reductase inhibitors like finasteride and dutasteride do not reduce the androgenic effects of metandienone. ![]() While it can be metabolized by 5α-reductase into methyl-1-testosterone (17α-methyl-δ 1-DHT), a more potent AAS, the drug has extremely low affinity for this enzyme and methyl-1-testosterone is thus produced in only trace amounts. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. Methandienone binds to and activates the androgen receptor (AR) in order to exert its effects. Footnotes: a = Ratio of androgenic to anabolic activity. It is said to be the most widely used AAS for such purposes both today and historically. Metandienone is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters. Metandienone was provided in the form of 2.5, 5 mg and 10mg oral tablets. b = No longer used and/or no longer marketed. Notes: Men produce about 3 to 11 mg testosterone per day (mean 7 mg/day in young men). Īndrogen replacement therapy formulations and dosages used in men It was given at a dosage of 5 to 10 mg/day in men and 2.5 mg/day in women. Metandienone was formerly approved and marketed as a form of androgen replacement therapy for the treatment of hypogonadism in men, but has since been discontinued and withdrawn in most countries, including in the United States. Metandienone is readily available without a prescription in certain countries such as Mexico, and is also manufactured in some Asian countries. It is currently a controlled substance in the United States and United Kingdom and remains popular among bodybuilders. ![]() As the CIBA product Dianabol, metandienone quickly became the first widely used AAS among professional and amateur athletes, and remains the most common orally active AAS for non-medical use. Metandienone was originally developed in 1955 by CIBA and marketed in Germany and the United States. The drug is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT), and has strong anabolic effects and moderate androgenic effects. Side effects of metandienone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire, estrogenic effects like fluid retention and breast enlargement, and liver damage. It is also used non-medically for physique- and performance-enhancing purposes. Metandienone, also known as methandienone or methandrostenolone and sold under the brand name Dianabol ( D-Bol) among others, is an androgen and anabolic steroid (AAS) medication which is still quite often used because of its affordability and effectiveness for bulking cycles.
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